What Is Epithalon (Epitalon)?
Epithalon — also written Epitalon, Epithalone, or historically Epithalamin (the parent extract) — is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (MW 390.34 Da). It was first characterised at the St. Petersburg Institute of Bioregulation and Gerontology by Professor Vladimir Khavinson’s group, who derived it from natural pineal gland extract. Today it is the most-studied of the Khavinson bioregulator series, with the majority of preclinical interest centred on its effects on telomerase activity and cellular ageing.
Researchers specifically searching for epithalon for sale, buy epithalon peptide, or epithalon peptide vial should note that EdgeChems stocks Epithalon 10mg lyophilised vials at ≥99% HPLC purity with batch Certificate of Analysis.
Epithalon vs Epitalon — Spelling Variants
Both spellings refer to the same tetrapeptide (Ala-Glu-Asp-Gly):
- Epithalon — used in most English-language publications originating from the Khavinson group
- Epitalon — common commercial and forum spelling; also used in some European publications
- Epithalone — occasional alternative spelling in older literature
- Epithalamin — the crude pineal extract from which Epithalon was isolated (not the pure tetrapeptide)
All refer to the same compound: H-Ala-Glu-Asp-Gly-OH.
NA-Epithalon Amidate
Researchers searching for na epithalon amidate, epithalon amidate for sale, buy epithalon amidate USA, or epithalon amidate certificate of analysis should be aware of the amidate salt form:
NA-Epithalon Amidate is the C-terminally amidated form of Epithalon (H-AEDG-NH₂ instead of -OH). The amidate modification confers improved resistance to C-terminal peptidase degradation in solution, resulting in greater stability in reconstituted form. Both the standard acetate and the NA-Epithalon Amidate are available from EdgeChems.
Epithalon / NA-Epithalon Amidate: edgechems.com/product/epitalon/ — 10mg vials, ≥99% HPLC, batch CoA included.
Preclinical Research Mechanisms
1. Telomerase Activation
The primary mechanistic research interest in Epithalon concerns its ability to activate telomerase (hTERT) in somatic cells that normally have low or absent telomerase expression. Multiple in-vitro studies from the Khavinson group and subsequent independent labs have shown up-regulation of hTERT mRNA and protein, with measurable elongation of telomeres in treated cell lines versus vehicle controls. This positions Epithalon as a unique tool for cellular ageing research.
2. Pineal Gland and Melatonin Regulation
In aged rodent models, Epithalon administration has been associated with restoration of pineal melatonin production to levels comparable with young controls. This circadian-resetting mechanism has implications for ageing research, sleep studies, and hypothalamic-pituitary axis models.
3. Antitumour Models
Several rodent studies — particularly from the N.N. Petrov National Medical Research Centre of Oncology — have examined the anti-proliferative and immunomodulatory effects of Epithalon in spontaneous and induced tumour models. The mechanism appears to involve p53-dependent apoptosis induction and immune surveillance restoration.
4. Lifespan and Healthspan Studies
Drosophila melanogaster and inbred mouse studies have reported statistically significant extensions in both median and maximum lifespan in Epithalon-treated cohorts versus vehicle controls. Mechanistically, this is attributed to the compound’s combined effects on telomere maintenance, antioxidant gene expression, and melatonin regulation.
Specification
| Parameter | Value |
|---|---|
| Sequence | Ala-Glu-Asp-Gly (H-AEDG-OH) |
| Molecular weight | 390.34 Da |
| CAS | 307297-39-8 |
| Format | Lyophilised vial (white powder) |
| Vial size | 10mg |
| Purity | ≥99% by HPLC |
| Reconstitution | Sterile or bacteriostatic water (1–2ml per vial) |
| Storage | −20°C (lyophilised); 4°C up to 7 days (reconstituted) |
| CoA | Batch HPLC CoA available on request |
Related Anti-Aging Research Compounds
Researchers investigating Epithalon’s longevity mechanisms frequently stack it with complementary compounds available from EdgeChems:
- GHK-Cu (Copper Peptide) — extracellular matrix remodelling, collagen synthesis, and antioxidant signalling studies
- MOTS-c — mitochondria-derived peptide for metabolic regulation and AMPK activation research
- SS-31 (Elamipretide) — mitochondrial bioenergetics and cardiolipin-targeting peptide
- FOXO4-DRI — senolytic peptide studied for selective senescent cell clearance
- NMN and NAD+ — NAD+ pathway compounds for sirtuin activation research
Browse the complete Anti-Aging & Longevity catalog.
Where to Buy Epithalon Online (USA)
EdgeChems is a USA-based research compound supplier stocking Epithalon 10mg vials at ≥99% HPLC purity. Each batch is tested by an independent third-party laboratory, and the Certificate of Analysis (CoA) with HPLC chromatogram is available on request. The NA-Epithalon Amidate form is also available.
- Epithalon 10mg vial (acetate): buy Epithalon for sale — EdgeChems
- Full Anti-Aging catalog: edgechems.com — Anti-Aging & Longevity
For laboratory and research use only. This product is not approved by any regulatory agency for human or veterinary therapeutic use. EdgeChems supplies research compounds exclusively to licensed researchers and institutions for in-vitro and in-vivo preclinical studies. Not for human consumption.