Phenibut HCL — 250mg Capsules | Research Grade | Buy Online USA
Phenibut HCL (β-phenyl-GABA hydrochloride; also written fenibut) is a synthetic GABA analogue (MW 215.68 Da as HCL salt). Each bottle contains 60 × 250mg capsules of Phenibut HCL at ≥99% HPLC purity with batch Certificate of Analysis.
Mechanism of Action
- GABA-B receptor agonism — The β-phenyl group enables CNS penetration and metabotropic GABA-B agonism. Primary mechanism in rodent anxiolytic and sedation models.
- Voltage-gated calcium channel modulation — Blocking of α₂-δ subunit VGCCs (analogous to gabapentin).
- Dopaminergic activity — Higher-dose protocols show dopamine release stimulation in rodent models.
Research Applications
- Anxiolytic and stress models (open-field, elevated plus-maze assays)
- Sleep architecture and slow-wave sleep regulation studies
- Cognitive performance models under stressor conditions
- GABA-B receptor pharmacology and ligand binding studies
Phenibut HCL vs FAA Form
This is the HCL (hydrochloride) salt — the standard water-soluble form used in the majority of published Phenibut research studies. Preferred for in-vitro assays and solution-based protocols due to superior aqueous solubility versus the FAA (free amino acid) form.
Specification
| CAS | 1078-21-3 (HCL salt) |
| Molecular weight | 215.68 Da (HCL) |
| Format | Oral capsule (no reconstitution required) |
| Dose per capsule | 250mg Phenibut HCL |
| Count | 60 capsules per bottle |
| Purity | ≥99% by HPLC |
| Storage | Room temperature, dry, away from light |
| CoA | Batch HPLC CoA available |
Related Research Compounds
Researchers sourcing Phenibut HCL also frequently buy: Bromantane (dopaminergic actoprotector); Noopept (synthetic nootropic dipeptide); Selank (anxiolytic heptapeptide); and Methylene Blue (mitochondrial electron carrier). Full Cognitive & Neuro catalog.
For research and laboratory use only. Not for human or veterinary consumption. EdgeChems supplies this compound exclusively for licensed preclinical research.
